It could be we are in a remote part of space that no one cares about. We are the Moose Jaw of planets.
The Americas may have been colonized by Europeans long before anyone in a small Inuit tribe in far northern Canada realized it had happened. There could be an urbanization component to the interstellar dwellings of higher species, in which all the neighboring solar systems in a certain area are colonized and in communication, and it would be impractical and purposeless for anyone to deal with coming all the way out to the random part of the spiral where we live.
There are a lot of interesting hypothesis of why we haven’t had our first contact. The following is the scariest.
There are scary predator civilizations out there, and most intelligent life knows better than to broadcast any outgoing signals and advertise their location.
This is an unpleasant concept and would help explain the lack of any signals being received by the SETI satellites. It also means that we might be the super naive newbies who are being unbelievably stupid and risky by ever broadcasting outward signals. There’s a debate going on currently about whether we should engage in METI (Messaging to Extraterrestrial Intelligence—the reverse of SETI) or not, and most people say we should not. Stephen Hawking warns, “If aliens visit us, the outcome would be much as when Columbus landed in America, which didn’t turn out well for the Native Americans.” Even Carl Sagan (a general believer that any civilization advanced enough for interstellar travel would be altruistic, not hostile) called the practice of METI “deeply unwise and immature,” and recommended that “the newest children in a strange and uncertain cosmos should listen quietly for a long time, patiently learning about the universe and comparing notes, before shouting into an unknown jungle that we do not understand.” Scary.